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Copa Airlines Curacao Airlines is known for its wide network throughout Latin America and the Caribbean, Copa Airlines is a well-known airline with its headquarters located in Panama. With a focus on contemporary fleet and excellent service, its core hub in Panama City allows for easy connections to over 80 destinations. Curaçao Airlines, on the other hand, specializes in regional connectivity, connecting Curaçao, a stunning island, with a number of Caribbean and South American towns.